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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG1
All Species:
22.73
Human Site:
Y845
Identified Species:
45.45
UniProt:
P19174
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19174
NP_002651.2
1290
148532
Y845
Q
L
W
F
P
S
N
Y
V
E
E
M
V
N
P
Chimpanzee
Pan troglodytes
XP_514650
1630
185027
Y1185
Q
L
W
F
P
S
N
Y
V
E
E
M
V
N
P
Rhesus Macaque
Macaca mulatta
XP_001087295
1291
148567
Y845
Q
L
W
F
P
S
N
Y
V
E
E
M
V
N
P
Dog
Lupus familis
XP_542998
1249
143812
Y805
Q
L
W
F
P
S
N
Y
V
E
E
M
V
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q62077
1302
149650
Y845
Q
L
W
F
P
S
N
Y
V
E
E
M
I
N
P
Rat
Rattus norvegicus
P10686
1290
148530
Y845
Q
L
W
F
P
S
N
Y
V
E
E
M
I
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q2VRL0
637
72514
D243
K
Y
A
F
A
A
S
D
Y
P
V
V
L
S
L
Frog
Xenopus laevis
Q32NH8
758
87399
I364
K
I
L
F
K
D
V
I
S
A
I
D
K
Y
A
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
I390
F
K
E
V
I
E
T
I
A
Q
Y
A
F
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
K701
A
G
Q
F
L
S
D
K
K
V
G
T
Y
V
E
Honey Bee
Apis mellifera
XP_624101
1134
132613
V740
K
H
A
I
I
T
N
V
H
R
Q
S
G
G
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
D546
P
G
Q
R
N
A
M
D
V
A
A
S
D
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79
99.5
93.2
N.A.
95.3
96.9
N.A.
N.A.
21.4
21.7
21.8
N.A.
21.4
45.1
N.A.
35.1
Protein Similarity:
100
79
99.7
94.5
N.A.
96.7
98.2
N.A.
N.A.
32.4
37.3
36.3
N.A.
40
62
N.A.
50
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
6.6
0
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
46.6
20
6.6
N.A.
20
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
17
0
9
17
0
0
9
17
9
9
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
9
17
0
0
0
9
9
0
0
% D
% Glu:
0
0
9
0
0
9
0
0
0
50
50
0
0
0
9
% E
% Phe:
9
0
0
75
0
0
0
0
0
0
0
0
9
0
0
% F
% Gly:
0
17
0
0
0
0
0
0
0
0
9
0
9
9
9
% G
% His:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
9
0
9
17
0
0
17
0
0
9
0
17
0
0
% I
% Lys:
25
9
0
0
9
0
0
9
9
0
0
0
9
9
0
% K
% Leu:
0
50
9
0
9
0
0
0
0
0
0
0
9
9
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
50
0
0
0
% M
% Asn:
0
0
0
0
9
0
59
0
0
0
0
0
0
42
0
% N
% Pro:
9
0
0
0
50
0
0
0
0
9
0
0
0
0
50
% P
% Gln:
50
0
17
0
0
0
0
0
0
9
9
0
0
0
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
9
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
59
9
0
9
0
0
17
0
17
0
% S
% Thr:
0
0
0
0
0
9
9
0
0
0
0
9
0
0
0
% T
% Val:
0
0
0
9
0
0
9
9
59
9
9
9
34
9
0
% V
% Trp:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
9
0
0
0
0
0
50
9
0
9
0
9
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _